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Pediatric Oncology Branch Home > Clinical Trials

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Clinical Trials

All Clinical Trial Listings

Please click the links below to go to each Clinical Trial Listing on this page:

Pilot   -   Phase 1   -   Phase 1 & 2   -   Phase 2   -   Natural History   -   Screening   -   Other

All Clinical Trials Information

Protocol Number	Title	Study Status	PI	Website	Section
Pilot
02C0259	Pilot Study of Allogeneic/Syngeneic Blood Stem Cell Transplantation in Patients with High-Risk and Recurrent Pediatric Sarcomas	Closed to Accrual	Baird, Kristin	Link	Sarcomas Hematopoietic Stem Cell Transplantation
07C0086	Pilot Study of Educational Interventions in Pediatric Hematopoietic Stem Cell Donors to Increase Knowledge of Donation and Transplantation Procedures	Open to Accrual	Wiener, Lori		Psychosocial Hematopoietic Stem Cell Transplantation GVHD
07C0206	A Pilot Study of Tumor Vaccination and RHIL-7 Following Standard Multimodality Therapy in Patients with High Risk Pediatric Solid Tumors	Open to Accrual	Mackall, Crystal	Link	Solid Tumors
08C0051	A Pilot Trial of WT1 Peptide-Loaded Allogeneic Dendritic Cell Vaccine and Donor Lymphocyte Infusion for WT1-Expressing Hematologic Malignancies	Open to Accrual	Wayne, Alan	Link	Hematologic Diseases
08C0148	A Pilot Study of Imatinib Mesylate in Children and Adults with Sclerotic Skin Changes of Chronic Graft-Versus-Host Disease	Closed to Accrual	Cowen, Edward	Link	GVHD
11C0113	A Pilot Study of Genetically Engineered NY-ESO-1 Specific (c259) T cells in HLA-A2+ Patients with Synovial Sarcoma	Open to Accrual	Mackall, Crystal		Solid Tumors
10C0105	A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children with Gliomas	Open to Accrual	Warren, Kathy		Neuro-Oncology
01C0125	Pilot Study of Non-myeloablative, HLA-matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies	Closed to Accrual	Wayne, Alan		Hematologic Diseases Hematopoietic Stem Cell Transplantation
97C0093	A Pilot Study of 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Pediatric Patients with Primary and Metastatic Brain Tumors	Closed to Accrual	Warren, Kathy		Neuro-Oncology
Phase 1
06C0233	A Phase I Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, NSC# 724772 IND# 69896) in Children with Refractory Solid Tumors or Refractory Leukemias	Open to Accrual	Widemann, Brigitte	Link	Hematologic Diseases Solid Tumors Pharmacology and Experimental Therapeutics
07C0040	A Phase I Trial of Monoclonal Antibody HGS-ETR2 (Lexatumumab) With or Without Interferon Gamma in Patients with Refractory Pediatric Solid Tumors	Closed to Accrual	Mackall, Crystal	Link	Solid Tumors
08C0007	A Phase I Study of Ipilimumab (Anti-CTLA4) in Children, Adolescents, and Young Adults with Treatment Refractory Cancer	Open to Accrual	Melinda, Merchant	Link	Solid Tumors Pharmacology and Experimental Therapeutics
08C0123	A Phase 1, Multi-Center, Dose Escalation Study of CAT-8015 in Children, Adolescents, and Young Adults with Refractory CD22+ Acute Lymphoblastic Leukemia (ALL) or Non-Hodgkin's Lymphoma (NHL)	Open to Accrual	Wayne, Alan	Link	Hematologic Diseases Pharmacology and Experimental Therapeutics
08C0180	Phase I Trial of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, Nexavar) in Children and Young Adults with Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas	Closed to Accrual	Widemann, Brigitte	Link	Neurofibromatosis Pharmacology and Experimental Therapeutics
09C0243	A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose)Polymerase and Temozolomide in Children with Recurrent/Refractory CNS Tumors	Open to Accrual	Warren, Kathy	Link	Neuro-Oncology Pharmacology and Experimental Therapeutics
10C0175	A Phase I Study of IMC-A12 (Anti-Insulin-Like Growth Factor-I Receptor Monoclonal Antibody) in Combination with CCI-779 (Temsirolimus) in Pediatric Patients with Recurrent or Refractory Solid Tumors	Open to Accrual	Widemann, Brigitte	Link	Solid Tumors Pharmacology and Experimental Therapeutics
10C0219	A Phase I Trial of Lenalidomide and Radiotherapy in Children with Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas	Open to Accrual	Warren, Kathy	Link	Neuro-Oncology
10C0220	Phase I Trial to Evaluate the Safety, Activity and Pharmacokinetics of Marqibo® (Vincristine Sulfate Liposomes Injection) in Children and Adolescents with Refractory Cancer	Open to Accrual	Wayne, Alan	Link	Solid Tumors Neuro-Oncology Hematologic Diseases
11C0047	Phase I trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors	Open to Accrual	Widemann, Brigitte	Link	Solid Tumors Neuro-Oncology Pharmacology and Experimental Therapeutics
11C0141	A Phase 1 Study of MK-2206, an AKT inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors or Leukemia	Open to Accrual	Widemann, Brigitte	Link	Pharmacology and Experimental Therapeutics Solid Tumors Hematologic Diseases
11C0142	A Phase 1 Study of JAK Inhibition (INCB018424) in Children with Relapsed or Refractory Solid Tumors, Leukemias, and Myeloproliferative Neoplasms	Open to Accrual	Widemann, Brigitte	Link	Solid Tumors Hematologic Diseases
09C0024	A Phase I Study of Merck Human Papilloma Virus (HPV) RecombinantVaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents, and Young Adults	Open to Accrual	Wood, Lauren Wiener, Lori		Psychosocial
11C0073	A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation from Related or Matched Unrelated Donors in Pediatric Patients with Solid Tumors and Leukemias	Open to Accrual	Baird, Kristin		Hematopoietic Stem Cell Transplantation Solid Tumors Hematologic Diseases
11C0161	A Phase 1 Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor AZD6244 Hydrogen Sulfate (Selumetinib Sulfate) in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)	Open to Accrual	Widemann, Brigitte		Pharmacology and Experimental Therapeutics Neurofibromatosis
11C0191	Phase 1 and Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma	Open to Accrual	Warren, Kathy		Neuro-Oncology
Phase 1 & 2
07C0189	Phase I/II Trial of Vandetanib (ZD6474, ZACTIMA) in Children and Adolescents with Hereditary Medullary Thyroid Carcinoma	Open to Accrual	Widemann, Brigitte	Link	Medullary Thyroid Carcinoma Pharmacology and Experimental Therapeutics
10C0178	A Phase 1/2 Study of PF-02341066, An Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and C-Met, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma	Open to Accrual	Widemann, Brigitte	Link	Solid Tumors Hematologic Diseases Pharmacology and Experimental Therapeutics
11Cxxx1	A Multi-Center Phase I-II Study of Continuous Flow Extracorporeal Photopheresis in Children with Chronic Graft-Versus-Host Disease	Pending Approval	Baird, Kristin		GVHD
Phase 2
04C0173	Phase II Study of UCN-01 in Relapsed or Refractory Systemic Anaplastic Large Cell and Mature T-Cell Lymphomas	Closed to Accrual	Wilson, Wyndham	Link	Hematologic Diseases
06C0043	Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated High Grade Malignant Peripheral Nerve Sheath Tumors	Open to Accrual	Widemann, Brigitte	Link	Neurofibromatosis Pharmacology and Experimental Therapeutics
08C0080	SARC Global Collaboration*: A Phase II Trial of R1507, a Recombinant Human Monoclonal Antibody to the Insulin-Like Growth Factor-1 Receptor for the treatment of Patients with Recurrent or Refractory Ewing’s Sarcoma, Osteosarcoma, Synovial Sarcoma, Rhabdomyosarcoma and Other Sarcomas	Open to Accrual	Helman, Lee	Link	Solid Tumors
08C0096	A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform Neurofibromas	Open to Accrual	Widemann, Brigitte	Link	Neurofibromatosis
08C0130	A Phase II Trial of Peginterferon alfa-2b (Pegintron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas	Open to Accrual	Widemann, Brigitte	Link	Neurofibromatosis
09C0104	A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Phase II.5 Study of AZD0530, a Selective Src Kinase Inhibitor, In Patients with Recurrent Osteosarcoma Localized to the Lung	Open to Accrual	Young Kim, Su	Link	Sarcomas
11C0115	Phase 2 Study of Bevacizumab in Children and Adults with Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma	Closed to Accrual	Widemann, Brigitte	Link	Neurofibromatosis Pharmacology and Experimental Therapeutics
08C0097	Multi-institutional Prospective Phase II Study of Montelukast for the Treatment of Bronchiolitis Obliterans following Allogeneic or Autologous Stem Cell Transplantation in Children and Adults	Open to Accrual	Gress, Ronald Baird, Kristin Wayne, Alan		GVHD
12C0058	A Phase II Study of Everolimus (RAD001) for Children with Neurofibromatosis Type-1 and Chemotherapy-Refractory Radiographic Progressive Low-Grade Gliomas	Open to Accrual	Warren, Kathy		Neuro-Oncology Neurofibromatosis
Natural History
04C0275	Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease with Laboratory and Clinical Correlates of Disease Activity	Open to Accrual	Yarchoan, Robert	Link
08C0079	Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1	Open to Accrual	Widemann, Brigitte	Link	Neurofibromatosis
04C0281	Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease	Open to Accrual	Pavletic, Stephen Baird, Kristin Wayne, Alan		GVHD
Screening
01C0157	Eligibility Screening and Tissue Procurement for the National Cancer Institute (NCI), Pediatric Oncology Branch (POB) Clinical Research Protocols	Open to Accrual	Mackall, Crystal
Other
01C0030	Short-Course EPOCH - Rituximab in Untreated CD-20+ HIV-Associated Lymphomas	Open to Accrual	Wilson, Wyndham	Link	Hematologic Diseases
02C0313	Cancer Risk in Xeroderma Pigmentosum Heterozygotes	Open to Accrual	Kraemer, Kenneth	Link
03C0278	A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI)	Open to Accrual	Warren, Kathy	Link	Neuro-Oncology
04C0102	Hematologic Malignancy Biology Study	Open to Accrual	Wayne, Alan		Hematologic Diseases
04CN282	Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development	Closed to Accrual	Widemann, Brigitte		Neurofibromatosis Pharmacology and Experimental Therapeutics
06C0219	An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients with Central Nervous System Tumors	Open to Accrual	Warren, Kathy	Link	Neuro-Oncology
07C0085	An Exploratory Study of the Use of Five Wishes as a Tool for Advanced Care Planning in Young Adults with Metastatic, Recurrent, or Progressive Cancer or HIV Infection	Open to Accrual	Wiener, Lori		Psychosocial
07C0110	Analysis of Stored Data Collected from Individuals Administered Neurobehavioral Assessments on IRB-approved Protocols	Open to Accrual	Hazra, Rohan
09C0054	A Group Wide Biology and Banking Study for Phase II Studies of R1507	Open to Accrual	Helman, Lee		Solid Tumors
10C0019	Development and validation of a symptom scale for children with chronic graft-versus-host disease	Open to Accrual	Wiener, Lori		Psychosocial Hematologic Diseases GVHD
10C0030	A Study of Bevacizumab, a Humanized Monoclonal Antibody Against Vascular Endothelial Growth Factor (VEGF), in Combination with Chemotherapy for Treatment of Osteosarcoma	Open to Accrual	Young Kim, Su		Solid Tumors
83C0022	Psychological Benefits of a Normalized Camping Experience for Children with Cancer	Open to Accrual	Chanock, Stephen
98C0037	Treatment of Children with Cancer	Open to Accrual	Mackall, Crystal
10C0086	Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies	Open to Accrual	Javed, Khan		Solid Tumors
10C0111	Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research-Network (CCRN) Children's Oncology Group	Open to Accrual	Mackall, Crystal
11C0132	Understanding the Psychosocial Needs of Parents Who Have Lost a Child to Cancer	Open to Accrual	Wiener, Lori	Link	Psychosocial
11CC0063	Evaluating Supportive Care for Children with Cancer: A Multi-Institutional Survey Study of Pediatric Oncology Patients and Parents	Open to Accrual	David, Wendler Deena, Levine		Psychosocial
09M0022	The Use of a Distress Thermometer in a Pediatric Research Setting: An Exploratory	Open to Accrual	Pao, Maryland Wiener, Lori		Psychosocial
09M0194	Characterizing Lone Parenting: A Multi-Institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children with Cancer	Open to Accrual	Pao, Maryland Wiener, Lori		Psychosocial
10M0192	An International Exploratory Study of the Characteristics of and Challenges for International Families Seeking Medical Care in the United States	Open to Accrual	Pao, Maryland Wiener, Lori		Psychosocial
OHSR5018	The Roles and Training Needs of Pediatric Psycho-Oncology Providers	Open to Accrual	Wiener, Lori		Psychosocial
OHSR4800	ShopTalk: An Examination of the Utility and Feasibility of a Therapeutic Board Game	Open to Accrual	Wiener, Lori		Psychosocial
OHSR4799	Psychosocial and Education Intervention for Pediatric Patients on Medical Isolation	Open to Accrual	Wiener, Lori		Psychosocial
08CC0032	Parental Permission and Adolescent Assent and Decision Making in Clinical Research	Open to Accrual	Grady, Christine Wiener, Lori		Psychosocial
99C0088	1H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy	Closed to Accrual	Warren, Kathy		Neuro-Oncology
11C0159	A Feasibility Trial using Molecular-Guided Therapy for the Treatment of Patients with Refractory or Recurrent Neuroblastoma	Open to Accrual	Javed, Khan		Solid Tumors

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