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Pediatric Oncology Branch Home > Clinical Trials

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Clinical Trials

All Clinical Trial Listings

Please click the links below to go to each Clinical Trial Listing on this page:

Pilot   -   Phase 1   -   Phase 1 & 2   -   Phase 2   -   Natural History   -   Screening   -   Other

All Clinical Trials Information

Protocol Number	Title	Study Status	PI	Website	Section
Pilot
07C0086	Pilot Study of Educational Interventions in Pediatric Hematopoietic Stem Cell Donors to Increase Knowledge of Donation and Transplantation Procedures	Currently Accruing	Wiener, Lori		Psychosocial Hematopoietic Stem Cell Transplantation GVHD
07C0206	A Pilot Study of Tumor Vaccination and RHIL-7 Following Standard Multimodality Therapy in Patients with High Risk Pediatric Solid Tumors	Not Currently Accruing	Mackall, Crystal	Link	Solid Tumors
08C0051	A Pilot Trial of WT1 Peptide-Loaded Allogeneic Dendritic Cell Vaccine and Donor Lymphocyte Infusion for WT1-Expressing Hematologic Malignancies	Currently Accruing	Wayne, Alan	Link	Hematologic Diseases
11C0113	A Pilot Study of Genetically Engineered NY-ESO-1 Specific (c259) T cells in HLA-A2+ Patients with Synovial Sarcoma	Currently Accruing	Mackall, Crystal	Link	Solid Tumors
Phase 1
08C0007	A Phase I Study of Ipilimumab (Anti-CTLA4) in Children, Adolescents, and Young Adults with Treatment Refractory Cancer	Currently Accruing	Melinda, Merchant	Link	Solid Tumors Pharmacology and Experimental Therapeutics
08C0123	A Phase 1, Multi-Center, Dose Escalation Study of CAT-8015 in Children, Adolescents, and Young Adults with Refractory CD22+ Acute Lymphoblastic Leukemia (ALL) or Non-Hodgkin's Lymphoma (NHL)	Not Currently Accruing	Wayne, Alan	Link	Hematologic Diseases Pharmacology and Experimental Therapeutics
10C0219	A Phase I Trial of Lenalidomide and Radiotherapy in Children with Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas	Currently Accruing	Warren, Kathy	Link	Neuro-Oncology
10C0220	Phase I Trial to Evaluate the Safety, Activity and Pharmacokinetics of Marqibo® (Vincristine Sulfate Liposomes Injection) in Children and Adolescents with Refractory Cancer	Currently Accruing	Wayne, Alan	Link	Solid Tumors Neuro-Oncology Hematologic Diseases
11C0047	Phase I trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors	Currently Accruing	Widemann, Brigitte	Link	Solid Tumors Neuro-Oncology Pharmacology and Experimental Therapeutics
09C0024	A Phase I Study of Merck Human Papilloma Virus (HPV) RecombinantVaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents, and Young Adults	Not Currently Accruing	Wood, Lauren Wiener, Lori		Psychosocial
11C0073	A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation from Related or Matched Unrelated Donors in Pediatric Patients with Solid Tumors and Leukemias	Currently Accruing	Baird, Kristin	Link	Hematopoietic Stem Cell Transplantation Solid Tumors Hematologic Diseases
11C0161	A Phase 1 Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor AZD6244 Hydrogen Sulfate (Selumetinib Sulfate) in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)	Currently Accruing	Widemann, Brigitte	Link	Pharmacology and Experimental Therapeutics Neurofibromatosis
11C0053	Phase I Study of Temsirolimus in Combination With Irinotecan and Temozolomide in Children, Adolescents, and Young Adults With Relapsed or Refractory Solid Tumors	Not Currently Accruing	Widemann, Brigitte	Link	Pharmacology and Experimental Therapeutics Solid Tumors
11C0191	Phase 1 and Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma	Currently Accruing	Warren, Kathy	Link	Neuro-Oncology
12C0112	Phase I Study of T Cells Expressing an Anti-CD19 Chimeric Receptor in Children and Young Adults with B Cell Malignancies	Currently Accruing	Wayne, Alan	Link	Hematologic Diseases
12C0208	Phase 1 Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients with Relapsed or Refractory Solid Tumors	Currently Accruing	Widemann, Brigitte		Pharmacology and Experimental Therapeutics Solid Tumors
13C0042	ADVL1211: A Phase I Study of XL184 (Cabozantinib, IND# 116059) in Children and Adolescents with Recurrent or Refractory Solid Tumors, Including CNS Tumors	Currently Accruing	Widemann, Brigitte		Solid Tumors Pharmacology and Experimental Therapeutics Neuro-Oncology
13C0064	An Open-Label, Multicenter, Single-Arm, Phase I Dose-Escalation with Efficacy Tail Extension Study of RO5185426 in Pediatric Patients with Surgically Incurable and Unresectable Stage IIIC or Stage IV Melanoma Harboring BRAFV600 Mutations	Currently Accruing	Merchant, Melinda		Solid Tumors
Phase 1 & 2
07C0189	Phase I/II Trial of Vandetanib (ZD6474, ZACTIMA) in Children and Adolescents with Hereditary Medullary Thyroid Carcinoma	Currently Accruing	Widemann, Brigitte	Link	Medullary Thyroid Carcinoma Pharmacology and Experimental Therapeutics
10C0178	A Phase 1/2 Study of PF-02341066, An Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and C-Met, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma	Currently Accruing	Widemann, Brigitte	Link	Solid Tumors Hematologic Diseases Pharmacology and Experimental Therapeutics
12C0135	Phase I/II Trial of Mithramycin in Children and Adults with Refractory Extracranial Solid Tumors (Phase I) or Ewing Sarcoma and EWS-FLI1 Fusion Transcript (Phase II)	Currently Accruing	Widemann, Brigitte	Link	Solid Tumors Pharmacology and Experimental Therapeutics
12C0213	PBTC-033 A Phase I/II Study of ABT-888, an Oral Poly (ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children with Newly Diagnosed Diffuse Pontine Glioma (DIPG)	Open to Accrual	Warren, Kathy		Neuro-Oncology
Phase 2
08C0130	A Phase II Trial of Peginterferon alfa-2b (Pegintron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas	Currently Accruing	Widemann, Brigitte	Link	Neurofibromatosis
09C0104	A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Phase II.5 Study of AZD0530, a Selective Src Kinase Inhibitor, In Patients with Recurrent Osteosarcoma Localized to the Lung	Currently Accruing	Baird, Kristin	Link	Sarcomas
08C0097	Multi-institutional Prospective Phase II Study of Montelukast for the Treatment of Bronchiolitis Obliterans following Allogeneic or Autologous Stem Cell Transplantation in Children and Adults	Currently Accruing	Gress, Ronald Baird, Kristin Wayne, Alan	Link	GVHD
12C0058	A Phase II Study of Everolimus (RAD001) for Children with Neurofibromatosis Type-1 and Chemotherapy-Refractory Radiographic Progressive Low-Grade Gliomas	Currently Accruing	Warren, Kathy	Link	Neuro-Oncology Neurofibromatosis
12C0098	A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (IND# 69896) in Children and Young Adults with Relapsed / Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma	Currently Accruing	Widemann, Brigitte	Link	Pharmacology and Experimental Therapeutics Solid Tumors
12C0148	SARC016: Phase II Study of the mTOR Inhibitor Everolimus in Combination With Bevacizumab in Patients With Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors	Currently Accruing	Widemann, Brigitte	Link	Pharmacology and Experimental Therapeutics Neurofibromatosis
12C0136	A Phase II Randomized Trial of Lenalidomide in Pediatric Patients With Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas	Currently Accruing	Warren, Kathy	Link	Neuro-Oncology
Natural History
04C0275	Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease with Laboratory and Clinical Correlates of Disease Activity	Currently Accruing	Yarchoan, Robert	Link
08C0079	Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1	Currently Accruing	Widemann, Brigitte	Link	Neurofibromatosis
04C0281	Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease	Currently Accruing	Pavletic, Stephen Baird, Kristin Wayne, Alan	Link	GVHD
12C0178	Longitudinal Assessment and Natural History Study of Children and Young Adults With Medullary Thyroid Carcinoma	Currently Accruing	Widemann, Brigitte	Link	Medullary Thyroid Carcinoma Pharmacology and Experimental Therapeutics
Screening
01C0157	Eligibility Screening and Tissue Procurement for the National Cancer Institute (NCI), Pediatric Oncology Branch (POB) Clinical Research Protocols	Currently Accruing	Mackall, Crystal
Other
01C0030	Short-Course EPOCH - Rituximab in Untreated CD-20+ HIV-Associated Lymphomas	Currently Accruing	Wilson, Wyndham	Link	Hematologic Diseases
02C0313	Cancer Risk in Xeroderma Pigmentosum Heterozygotes	Currently Accruing	Kraemer, Kenneth	Link
03C0278	A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI)	Open to Accrual	Warren, Kathy	Link	Neuro-Oncology
04C0102	Hematologic Malignancy Biology Study	Currently Accruing	Wayne, Alan	Link	Hematologic Diseases
06C0219	An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients with Central Nervous System Tumors	Currently Accruing	Warren, Kathy	Link	Neuro-Oncology
07C0110	Analysis of Stored Data Collected from Individuals Administered Neurobehavioral Assessments on IRB-approved Protocols	Currently Accruing	Wolters, Pamela	Link
83C0022	Psychological Benefits of a Normalized Camping Experience for Children with Cancer	Currently Accruing	Chanock, Stephen	Link
98C0037	Treatment of Children with Cancer	Currently Accruing	Mackall, Crystal	Link
10C0086	Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies	Currently Accruing	Javed, Khan	Link	Solid Tumors
10C0111	Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research-Network (CCRN) Children's Oncology Group	Open to Accrual	Mackall, Crystal	Link
11C0132	Understanding the Psychosocial Needs of Parents Who Have Lost a Child to Cancer	Currently Accruing	Wiener, Lori	Link	Psychosocial
11CC0063	Evaluating Supportive Care for Children with Cancer: A Multi-Institutional Survey Study of Pediatric Oncology Patients and Parents	Currently Accruing	David, Wendler Deena, Levine	Link	Psychosocial
09M0022	The Use of a Distress Thermometer in a Pediatric Research Setting: An Exploratory	Currently Accruing	Pao, Maryland Wiener, Lori	Link	Psychosocial
09M0194	Characterizing Lone Parenting: A Multi-Institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children with Cancer	Currently Accruing	Pao, Maryland Wiener, Lori	Link	Psychosocial
OHSR5018	The Roles and Training Needs of Pediatric Psycho-Oncology Providers	Currently Accruing	Wiener, Lori		Psychosocial
OHSR4800	ShopTalk: An Examination of the Utility and Feasibility of a Therapeutic Board Game	Currently Accruing	Wiener, Lori		Psychosocial
OHSR4799	Psychosocial and Education Intervention for Pediatric Patients on Medical Isolation	Currently Accruing	Wiener, Lori		Psychosocial
12C0155	Acceptance and Commitment Therapy for Adolescents and Adults With Neurofibromatosis Type 1 and Chronic Pain: A Pilot Study	Currently Accruing	Peron, Staci	Link	Psychosocial Neurofibromatosis
12C0160	Validation of the English Version of the Pain Interference Index and the Pain Rating Scale in Children, Adolescents, and Young Adults With Chronic Illness and Their Parents	Currently Accruing	Peron, Staci	Link	Psychosocial Neurofibromatosis Solid Tumors Hematologic Diseases
12C0206	Understanding the Perceived Influence of Childhood Cancer on the Parents' Marital/partner Relationship: A Descriptive Study	Currently Accruing	Wiener, Lori		Psychosocial

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