Clinical Trials
| Protocol Number | Title | Study Status | PI | Website | Section | |
|---|---|---|---|---|---|---|
| Pilot | ||||||
| 07C0206 | A Pilot Study of Tumor Vaccination and RHIL-7 Following Standard Multimodality Therapy in Patients with High Risk Pediatric Solid Tumors | Not Currently Accruing |
Mackall, Crystal |
Link |
Solid Tumors |
|
| 11C0113 | A Pilot Study of Genetically Engineered NY-ESO-1 Specific (c259) T cells in HLA-A2+ Patients with Synovial Sarcoma | Currently Accruing |
Mackall, Crystal |
Link |
Solid Tumors |
|
| Phase 1 | ||||||
| 08C0007 | A Phase I Study of Ipilimumab (Anti-CTLA4) in Children, Adolescents, and Young Adults with Treatment Refractory Cancer | Currently Accruing |
Melinda, Merchant |
Link |
Solid Tumors Pharmacology and Experimental Therapeutics |
|
| 10C0220 | Phase I Trial to Evaluate the Safety, Activity and Pharmacokinetics of Marqibo® (Vincristine Sulfate Liposomes Injection) in Children and Adolescents with Refractory Cancer | Currently Accruing |
Wayne, Alan |
Link |
Solid Tumors Neuro-Oncology Hematologic Diseases |
|
| 11C0047 | Phase I trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors | Currently Accruing |
Widemann, Brigitte |
Link |
Solid Tumors Neuro-Oncology Pharmacology and Experimental Therapeutics |
|
| 11C0073 | A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation from Related or Matched Unrelated Donors in Pediatric Patients with Solid Tumors and Leukemias | Currently Accruing |
Baird, Kristin |
Link |
Hematopoietic Stem Cell Transplantation Solid Tumors Hematologic Diseases |
|
| 11C0053 | Phase I Study of Temsirolimus in Combination With Irinotecan and Temozolomide in Children, Adolescents, and Young Adults With Relapsed or Refractory Solid Tumors | Not Currently Accruing |
Widemann, Brigitte |
Link |
Pharmacology and Experimental Therapeutics Solid Tumors |
|
| 12C0208 | Phase 1 Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients with Relapsed or Refractory Solid Tumors | Currently Accruing |
Widemann, Brigitte |
Pharmacology and Experimental Therapeutics Solid Tumors |
||
| 13C0042 | ADVL1211: A Phase I Study of XL184 (Cabozantinib, IND# 116059) in Children and Adolescents with Recurrent or Refractory Solid Tumors, Including CNS Tumors | Currently Accruing |
Widemann, Brigitte |
Solid Tumors Pharmacology and Experimental Therapeutics Neuro-Oncology |
||
| 13C0064 | An Open-Label, Multicenter, Single-Arm, Phase I Dose-Escalation with Efficacy Tail Extension Study of RO5185426 in Pediatric Patients with Surgically Incurable and Unresectable Stage IIIC or Stage IV Melanoma Harboring BRAFV600 Mutations | Currently Accruing |
Merchant, Melinda |
Solid Tumors |
||
| Phase 1 & 2 | ||||||
| 10C0178 | A Phase 1/2 Study of PF-02341066, An Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and C-Met, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma | Currently Accruing |
Widemann, Brigitte |
Link |
Solid Tumors Hematologic Diseases Pharmacology and Experimental Therapeutics |
|
| 12C0135 | Phase I/II Trial of Mithramycin in Children and Adults with Refractory Extracranial Solid Tumors (Phase I) or Ewing Sarcoma and EWS-FLI1 Fusion Transcript (Phase II) | Currently Accruing |
Widemann, Brigitte |
Link |
Solid Tumors Pharmacology and Experimental Therapeutics |
|
| Phase 2 | ||||||
| 12C0098 | A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (IND# 69896) in Children and Young Adults with Relapsed / Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma | Currently Accruing |
Widemann, Brigitte |
Link |
Pharmacology and Experimental Therapeutics Solid Tumors |
|
| Other | ||||||
| 10C0086 | Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies | Currently Accruing |
Javed, Khan |
Link |
Solid Tumors |
|
| 12C0160 | Validation of the English Version of the Pain Interference Index and the Pain Rating Scale in Children, Adolescents, and Young Adults With Chronic Illness and Their Parents | Currently Accruing |
Peron, Staci |
Link |
Psychosocial Neurofibromatosis Solid Tumors Hematologic Diseases |
|