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Pharmacology and Experimental Therapeutics (Phase I/II)

Clinical Trials

Pharmacology and Experimental Therapeutics (Phase I/II)

All Clinical Trials Information

Protocol Number Title Study Status PI Website Section
Phase 1
08C0007 A Phase I Study of Ipilimumab (Anti-CTLA4) in Children, Adolescents, and Young Adults with Treatment Refractory Cancer Not Currently Accruing Melinda, Merchant
Link Solid Tumors
Pharmacology and Experimental Therapeutics
08C0123 A Phase 1, Multi-Center, Dose Escalation Study of CAT-8015 in Children, Adolescents, and Young Adults with Refractory CD22+ Acute Lymphoblastic Leukemia (ALL) or Non-Hodgkin's Lymphoma (NHL) Currently Accruing Shah, Nirali
Link Hematologic Diseases
Pharmacology and Experimental Therapeutics
11C0047 Phase I trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors Not Currently Accruing Widemann, Brigitte
Link Solid Tumors
Neuro-Oncology
Pharmacology and Experimental Therapeutics
11C0161 A Phase 1 Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor AZD6244 Hydrogen Sulfate (Selumetinib Sulfate) in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN) Currently Accruing Widemann, Brigitte
Link Pharmacology and Experimental Therapeutics
Neurofibromatosis
12C0208 Phase 1 Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients with Relapsed or Refractory Solid Tumors Not Currently Accruing Widemann, Brigitte
  Pharmacology and Experimental Therapeutics
Solid Tumors
13C0042 ADVL1211: A Phase I Study of XL184 (Cabozantinib, IND# 116059) in Children and Adolescents with Recurrent or Refractory Solid Tumors, Including CNS Tumors Currently Accruing Widemann, Brigitte
  Solid Tumors
Pharmacology and Experimental Therapeutics
Neuro-Oncology
Phase 1 & 2
07C0189 Phase I/II Trial of Vandetanib (ZD6474, ZACTIMA) in Children and Adolescents with Hereditary Medullary Thyroid Carcinoma Currently Accruing Widemann, Brigitte
Link Medullary Thyroid Carcinoma
Pharmacology and Experimental Therapeutics
10C0178 A Phase 1/2 Study of PF-02341066, An Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and C-Met, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma Currently Accruing Widemann, Brigitte
Link Solid Tumors
Hematologic Diseases
Pharmacology and Experimental Therapeutics
12C0135 Phase I/II Trial of Mithramycin in Children and Adults with Refractory Extracranial Solid Tumors (Phase I) or Ewing Sarcoma and EWS-FLI1 Fusion Transcript (Phase II) Currently Accruing Widemann, Brigitte
Link Solid Tumors
Pharmacology and Experimental Therapeutics
14C0013 A Phase I/II Trial of Ganetespib in Combination with the mTOR Inhibitor Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors Currently Accruing Widemann, Brigitte
Link Pharmacology and Experimental Therapeutics
Phase 2
12C0098 A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (IND# 69896) in Children and Young Adults with Relapsed / Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma Currently Accruing Widemann, Brigitte
Link Pharmacology and Experimental Therapeutics
Solid Tumors
12C0148 SARC016: Phase II Study of the mTOR Inhibitor Everolimus in Combination With Bevacizumab in Patients With Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors Currently Accruing Widemann, Brigitte
Link Pharmacology and Experimental Therapeutics
Neurofibromatosis
13C0208 Phase II Trial of Vandetanib (ZD6474, Caprelsa(R)) in Children and Adults with Wild-Type Gastrointestinal Stromal Tumors Currently Accruing Widemann, Brigitte
Link Pharmacology and Experimental Therapeutics
Natural History
12C0178 Longitudinal Assessment and Natural History Study of Children and Young Adults With Medullary Thyroid Carcinoma Currently Accruing Widemann, Brigitte
Link Medullary Thyroid Carcinoma
Pharmacology and Experimental Therapeutics
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