Clinical Trials
| Protocol Number | Title | Study Status | PI | Website | Section | |
|---|---|---|---|---|---|---|
| Phase 1 | ||||||
| 10C0219 | A Phase I Trial of Lenalidomide and Radiotherapy in Children with Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology |
|
| 10C0220 | Phase I Trial to Evaluate the Safety, Activity and Pharmacokinetics of Marqibo® (Vincristine Sulfate Liposomes Injection) in Children and Adolescents with Refractory Cancer | Currently Accruing |
Wayne, Alan |
Link |
Solid Tumors Neuro-Oncology Hematologic Diseases |
|
| 11C0047 | Phase I trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors | Currently Accruing |
Widemann, Brigitte |
Link |
Solid Tumors Neuro-Oncology Pharmacology and Experimental Therapeutics |
|
| 11C0191 | Phase 1 and Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology |
|
| 13C0042 | ADVL1211: A Phase I Study of XL184 (Cabozantinib, IND# 116059) in Children and Adolescents with Recurrent or Refractory Solid Tumors, Including CNS Tumors | Currently Accruing |
Widemann, Brigitte |
Solid Tumors Pharmacology and Experimental Therapeutics Neuro-Oncology |
||
| Phase 1 & 2 | ||||||
| 12C0213 | PBTC-033 A Phase I/II Study of ABT-888, an Oral Poly (ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children with Newly Diagnosed Diffuse Pontine Glioma (DIPG) | Open to Accrual |
Warren, Kathy |
Neuro-Oncology |
||
| Phase 2 | ||||||
| 12C0058 | A Phase II Study of Everolimus (RAD001) for Children with Neurofibromatosis Type-1 and Chemotherapy-Refractory Radiographic Progressive Low-Grade Gliomas | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology Neurofibromatosis |
|
| 12C0136 | A Phase II Randomized Trial of Lenalidomide in Pediatric Patients With Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology |
|
| Other | ||||||
| 03C0278 | A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI) | Open to Accrual |
Warren, Kathy |
Link |
Neuro-Oncology |
|
| 06C0219 | An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients with Central Nervous System Tumors | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology |
|